Genomics

You've probably heard "genome" used interchangeably with "DNA," "genetic code," and "blueprint of life." All three framings are imprecise in ways that will trip you up once you start doing real work.

In Module 1 you learned that any two humans share about 99.9% of their genome sequence.

In Module 2 you learned that any two humans differ at roughly 4–5 million positions.

In Module 3 you learned how sequencing works: you fragment DNA, sequence billions of short reads, and get back a FASTQ file.

You've learned what a genome is, how to read it, and how to interpret variation in it.

In Module 2 you learned that any two humans differ at roughly 4–5 million positions.

Everything in Module 6 was about single-gene disease: one broken gene, one disease.

Every module so far has been about reading the genome: sequencing it, aligning it, interpreting variants, measuring expression, associating variants with disease.

A standard dose of codeine relieves pain in most people.

Every module so far has been about what genomics can do.

Cancer is, at its core, a disease of the genome.

Every module so far has described established science — things we know, tools that work, clinical applications that exist.

You've covered 12 modules.